Abstract
The synthesis and pharmacological profile of a novel series of 7-methoxybenzofuran-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).
MeSH terms
-
3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
-
Administration, Oral
-
Animals
-
Asthma / drug therapy
-
Benzamides / adverse effects
-
Benzamides / chemical synthesis
-
Benzamides / pharmacology
-
Benzofurans / adverse effects
-
Benzofurans / chemical synthesis*
-
Benzofurans / pharmacology*
-
Cyclic Nucleotide Phosphodiesterases, Type 4
-
Eosinophilia / drug therapy
-
Guinea Pigs
-
Inhibitory Concentration 50
-
Phosphodiesterase Inhibitors / adverse effects
-
Phosphodiesterase Inhibitors / chemical synthesis*
-
Phosphodiesterase Inhibitors / pharmacology
-
Pyridines / adverse effects
-
Pyridines / chemical synthesis
-
Pyridines / pharmacology
-
Rolipram / adverse effects
-
Rolipram / analogs & derivatives
-
Rolipram / pharmacology
-
Structure-Activity Relationship
-
Vomiting / chemically induced
Substances
-
Benzamides
-
Benzofurans
-
Phosphodiesterase Inhibitors
-
Pyridines
-
3',5'-Cyclic-AMP Phosphodiesterases
-
Cyclic Nucleotide Phosphodiesterases, Type 4
-
Rolipram
-
piclamilast